publications

2023

  • A bacterial effector protein promotes nuclear translocation of Stat3 to induce IL-10. Berneking L, Bekere I, Rob S, Schnapp M, Huang J, Ruckdeschel K & Aepfelbacher M ____ 2023 Oct | EUR J CELL BIOL
  • Coupling-Based Sensor with a Microwave Resonator for Single Nanoscale Particles Detection. Lucijan Grzegorzewski, Jann Harberts, Robert Zierold, Robert H. Blick ____ 2023 Oct | IEEE Nano-Bio-Electronics
  • Millisecond cryo-trapping by the spitrobotcrystal plunger simplifies time-resolved crystallography. Mehrabi Pedram, Sung Sihyun, von Stetten David, Prester Andreas, Hatton Caitlin E., Kleine-Döpke Stephan, Berkes Alexander, Gore Gargi, Leimkohl Jan-Philipp, Schikora Hendrik, Kollewe Martin, Rohde Holger, Wilmanns Matthias, Tellkamp Friedjof, Schulz Eike C. ____ 2023 April | Nature Communications

2022

  • MINFLUX imaging of a bacterial molecular machine at nanometer resolution. Carsten A, Rudolph M, Weihs T, Schmidt R, Jansen I, Wurm CA, Diepold A, Failla AV, Wolters M, Aepfelbacher M ____ 2022 Dec | Methods Appl Fluoresc.
  • Rapid and efficient room-temperature serial synchrotron crystallography using the CFEL TapeDrive. Zielinski KA, Prester A, ….. + 15 authors …., Betzel C, Rohde H, Aepfelbacher M, Chapman HN, Perbandt M, Steiner RA and Oberthuer D ____ 2022 Okt | IUCrJ
  • Label-Free Single-Cell Counting and Characterization in the GHz-range. Gwozdz PV, Harberts J, Zierold R, Blick RH ____ 2022 Oct  | Frequenz
  • C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus. Paulowski L, Beckham KSH, Johansen MD, Berneking L, Van N, Degefu Y, Staack S, Vasquez Sotomayor F, Asar L, Rohde H, Aldridge BB, Aepfelbacher M, Parret A, Wilmanns M, Kremer L, Combrink K, Maurer FP ____ 2022 Sept | PNAS Nexus
  • The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness. Lagune M, Le Moigne V, Johansen MD, Vásquez Sotomayor F, Daher W, Petit C, Cosentino G, Paulowski L, Gutsmann T, Wilmanns M, Maurer FP, Herrmann JL, Girard-Misguich F, Kremer L ____ 2022 Aug | PLoS pathogens
  • Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease. Srinivasan V, Brognaro H, … + 17 authors …., Perbandt M, …. + 25 authors …  , Pearson AR, Chapman HN, Hinrichs W, Wrenger C, Meents A & Betzel C ____ 2022 Aug | Communications biology
  • The effect of secondary electrons on radiolysis as observed by in liquid TEM: the role of window material and electrical bias. Bultema LA, Bücker R, Schulz EC, Tellkamp F, Gonschior J, Miller RJD, Kassier GH ____ 2022 June | Ultramicroscopy
  • Live imaging of Yersinia translocon formation and immune recognition in host cells. Rudolph M, Carsten A, Kulnik S, Aepfelbacher M, Wolters M ____ 2022 May |  PLoS Pathog.
  • Structural basis to repurpose boron-based proteasome inhibitors Bortezomib and Ixazomib as β-lactamase inhibitors. Perbandt M, Werner N, Prester A, Rohde H, Aepfelbacher M, Hinrichs W, Betzel C ___ 2022 April | Scientific reports
  • The prion protein and its ligands: Insights into structure-function relationships. Shafiq M, Da Vela S, Amin L, Younas N, Harris DA, Zerr I, Altmeppen HC, Svergun D, Glatzel M ____ 2022 Feb | Biochim Biophys Acta Mol Cell Res.
  • Best practices for time-resolved serial synchrotron crystallography. Schulz EC, Yorke Briony A, Pearson AR and Mehrabi P ____ 2022 Jan | J. Acta Cryst.

2021

  • An environmental control box for serial crystallography enables multi-dimensional experiments. Mehrabi P, von Stetten D, Leimkohl J-P, Tellkamp F, Schulz EC ____ 2021 Nov | bioRxiv
  • Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies. Linsenmeier L, Mohammadi B, Shafiq M, Frontzek K, Bar J, Shrivastava AN, Damme M, Song F, Schwarz A, Da Vela S, Massignan T, Jung S, Correia A, Schmitz M, Puig B, Hornemann S, Zerr I, Tatzelt J, Biasini E, Saftig P, Schweizer M, Svergun D, Amin L, MazzolaF, Varani L, Thapa S, Gilch S, Schatzl H, Harris DA, Triller A, Mikhaylova M, Aguzzi A, Altmeppen HC, Glatzel M ____ 2021 Nov | Sci Adv.
  • Conserved and specialized functions of Type VII secretion systems in non-tuberculous mycobacteria. Lagune M, Petit C, Sotomayor FV, Johansen MD, Beckham KSH, Ritter C, Girard-Misguich F, Wilmanns M, Kremer L, Maurer FP, Herrmann JL ____ 2021 July | Microbiology
  • Stimulation of Local Cytosolic Calcium Release by Photothermal Heating for Studying Intra- and Intercellular Calcium Waves. Zhu D, Feng L, Feliu N, Guse AH, Parak WJ ____ 2021 Jun | Adv Mater
  • Structure of the mycobacterial ESX-5 type VII secretion system pore complex. Beckham KSH, Ritter C, Chojnowski G, Ziemianowicz DS, Mullapudi E, Rettel M, Savitski MM, Mortensen SA, Kosinski J, Wilmanns M ____ 2021 Jun | Science advances
  • A simple vapor diffusion method enables protein crystallization inside the HARE serial crystallography chip. Norton-Baker B, Mehrabi P, Boger J, Schönherr R, von Stetten D, Schikora H, O Kwok A, Martin RW, Miller RJD, Redecke L, Schulz EC ____ 2021 May | Acta Cryst.
  • X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Günther S, …+ 97 authors …….., Schulz EC, Mehrabi P, Pearson AR, Betzel C, Meents A ____ 2021 May, Science
  • Secretome characterization of clinical isolates from the Mycobacterium abscessus complex provides insight into antigenic differences. Cornejo-Granados F, Kohl TA, Sotomayor FV, Andres S, Hernández-Pando R, Hurtado-Ramirez JM, Utpatel C, Niemann S, Maurer FP & Ochoa-Leyva A ____ 2021 May | BMC GENOMICS
  • Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: a systematic comparison. Mehrabi P, Bücker R, Bourenkov G, Ginn HM, von Stetten D, Müller-Werkmeister HM, Kuo A, Morizumi T, Eger BT, Ou W-L, Oghbaey S, Sarracini A, Besaw JE, Pare-Labrosse O, Meier S, Schikora H, Tellkamp F, Marx A, Sherrell DA, Axford D, Owen RL, Ernst OP, Pai EF, Schulz EC, Miller RCD ____ 2021 Mar | Science Advances
  • Environmental Liquid Cell Technique for Improved Electron Microscopic Imaging of Soft Matter in Solution. Azim S, Bultema LA, de Kock MB, Osorio-Blanco EF, Calderón M, Gonschior J, Leimkohl J-P, Tellkamp F, Bücker R, Schulz EC, Keskin S, de Jonge N, Kassier GH, Miller RJD ____ 2021 Feb | Microsc Microanal

2020

  • Structure of the mycobacterial ESX-5 Type VII Secretion System hexameric pore complex
    • Kathrine S. H. Beckham, Christina Ritter, Grzegorz Chojnowski, Edukondalu Mullapudi, Mandy Rettel, Mikhail M. Savitski, Simon A. Mortensen, Jan Kosinski, Matthias Wilmanns
      2020 Nov. 17 | bioRxiv
  • A Giant Extracellular Matrix Binding Protein of Staphylococcus epidermidis Binds Surface-Immobilized Fibronectin via a Novel Mechanism
    • Henning Büttner, Markus Perbandt, Thomas Kohler, Alexey Kikhney, Manuel Wolters, Martin Christner, Marisol Heise, Jérôme Wilde, Samira Weißelberg, Anna Both, Christian Betzel, Sven Hammerschmidt, Dmitri Svergun, Martin Aepfelbacher, Holger Rohde
      2020 Oct. 20 | Molecular Biology and Physiology
  • Protein-crystal detection with a compact multimodal multiphoton microscope
    • Qing-di Cheng, Hsiang-Yu Chung, Robin Schubert, Shih-Hsuan Chia, Sven Falke, Celestin Nzanzu Mudogo, Franz X. Kärtner, Guoqing Chang & Christian Betzel
      2020 Oct. 13 | COMMUNICATIONS BIOLOGY
  • The crystal structure of mycobacterial epoxide hydrolase A
    • Eike C. Schulz, Sara R. Henderson, Boris Illarionov, Thomas Crosskey, Stacey M. Southall, Boris Krichel, Charlotte Uetrecht, Markus Fischer & Matthias Wilmanns 
      2020 Oct. 06 | Scientific Reports
  • The pMy vector series: A versatile cloning platform for the recombinant production of mycobacterial proteins in Mycobacterium smegmatis
    • Katherine S. H. Beckham, Sonja Staack, Matthias Wilmanns, Annabel H. A. Parret
      2020 Oct. 2 | Protein Science
  • Microfluidic polyimide gas dynamic virtual nozzles for serial crystallography
    • Mohammad Vakili, Ramakrishna Vasireddi, Paul V. Gwozdz, Diana C. F. Monteiro, Michael Heymann, Robert H. Blick, and Martin Trebbin
      2020 August 07 | Rev. Sci. Instrum.
  • Neurite guidance and neuro-caging on steps and grooves in 2.5 dimensions
    • Cornelius Fendler, Jann Harberts, Lars Rafeldt, Gabriele Loers, Robert Zierold and Robert H. Blick
      2020 July 14 | Nanoscale Advances
  • Bedaquiline-Resistant Tuberculosis: Dark Clouds on the Horizon
  • A Temperature-Controlled Patch Clamp Platform Demonstrated on Jurkat T Lymphocytes and Human Induced Pluripotent Stem Cell-Derived Neurons
    • Jann Harberts, Max Kusch, John O’Sullivan, Robert Zierold and Robert H. Blick
      2020 May 22 | Bioengineering
  • Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex
    • Matthias Merker, Thomas A. Kohl, Ivan Barilar, Sönke Andres, Philip W. Fowler, Erja Chryssanthou, Kristian Ängeby, Pontus Jureen, Danesh Moradigaravand, Julian Parkhill, Sharon J. Peacock, Thomas Schön, Florian P. Maurer, Timothy Walker, Claudio Köser and Stefan Niemann
      2020 Mar 6 | Genome Med.
  • Serial protein crystallography in an electronmicroscope
    • Robert Bücker, Pascal Hogan-Lamarre, Pedram Mehrabi, Eike C. Schulz, Lindsey A. Bultema,Yaroslav Gevorkov, Wolfgang Brehm, Oleksandr Yefanov, Dominik Oberthür, Günther H. Kassier & R.J. Dwayne Miller
      2020 Feb. 21 | Nat Commun
  • Bedaquiline-resistant Tuberculosis: Dark Clouds on the Horizon
    • Sönke Andres, Matthias Merker, Jan Heyckendorf, Barbara Kalsdorf, Rudolf Rumetshofer, Alexander Indra, Sabine Hofmann-Thiel, Harald Hoffmann, Christoph Lange, Stefan Niemann, and Florian P Maurer
      2020 Feb 13 | Am J Respir Crit Care Med.
  • In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors
    • Karol Nass, Lars Redecke, M. Perbandt, O. Yefanov, M. Klinge, R. Koopmann, F. Stellato, A. Gabdulkhakov, R. Schönherr, D. Rehders, J.M. Lahey-Rudolph, A. Aquila,A. Barty, S. Basu, R.B. Doak, R. Duden, M. Frank, R. Fromme, S. Kassemeyer, G. Katona, R. Kirian, H. Liu, I. Majoul, J.M. Martin-Garcia, M. Messerschmidt, R.L. Shoeman, U. Weierstall, S. Westenhoff, T.A. White, G.J. Williams, C.H. Yoon, N. Zatsepin, P. Fromme, M. Duszenko, H.N. Chapman & C. Betzel
      2020 Jan 30 | Nat Commun.
  • The HARE chip for efficient time-resolved serialsynchrotron crystallography
    • Pedram Mehrabi, Henrike M. Müller-Werkmeister, Jan-Philipp Leimkohl, Hendrik Schikora, Jelena Ninkovic, Silvia Krivokuca, Ladislav Andriček, Sascha W. Epp, Darren Sherrell, Robin L. Owen, Arwen R. Pearson, Friedjof Tellkamp, Eike C. Schulz and R. J. Dwayne Miller
      2020 Jan. 20 | Nat Methods
  • A structural overview of the ion channels of the TRPM family.
    • Yihe Huang, Ralf Fliegert, Andreas H. Guse, Wei Lü, Juan Du
      2020 Jan. | Cell Calcium
  • Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR).
    • Ondřej Baszczyňski, Joanna M. Watt, Monika D. Rozewitz, Ralf Fliegert, Andreas H. Guse, Barry V. L. Potter
      2020 Jan. 13 | RSC Adv.

2019 | 2018

  • A multi-channel in situ light scattering instrument utilized for monitoring protein aggregation and liquid dense cluster formation
    • Sven Falke, Hévila Brognaro, Arayik Martirosyan, Karsten Dierks, Christian Betzel 2019 Dec. 13 | Heliyon
  • Structural properties of [2Fe-2S] ISCA2-IBA57: a complex of the mitochondrial iron-sulfur cluster assembly machinery.
    • Veronica Nasta, Stefano Da Vela, Spyridon Gourdoupis, Simone Ciofi-Baffoni, Dmitri I. Svergun, Lucia Banci: Sci Rep.
      2019 Dec. 12 | Sci Rep.
  • Multi-Step Concanavalin A Phase Separation and Early-Stage Nucleation Monitored Via Dynamic and Depolarized Light Scattering.
    • Hévila Brognaro, Sven Falke, Celestin Nzanzu Mudogo and Christian Betzel: Crystals
      2019 Nov. 26 | Crystals
  • A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3.
    • Christian Dupont, Yushu Chen, Zhujun Xu, Françoise Roquet-Banères, Mickaël Blaise, Anne-Kathrin Witt, Faustine Dubar, Christophe Biot, Yann Guérardel, Florian P. Maurer, Shu-Sin Chng and Laurent Kremer: JBC
      2019 Nov. 15 | J Biol Chem.
  • Protein phase separation and determinants of in cell crystallization.
    • Celestin N. Mudogo, Sven Falke, Hévila Brognaro, Michael Duszenko and Christian Betzel: Traffic
      2019 Oct. 30 | Traffic
  • Rifamycin derivatives active against pathogenic rapidly-growing mycobacteria.
    • Keith D. Combrink, Andrea RamirezRamos, StephanieSpring, Sebastian Schmidl, Kira Elizondo, Petronilo Morin, Bryant De Jesus and Florian P. Maurer: Bioorg Med Chem Lett
      2019 Aug 15 | Bioorg Med Chem Lett.
  • Culturing and patch clamping of Jurkat T cells and neurons on Al2O3 coated nanowire arrays of altered morphology
    • Jann Harberts, Robert Zierold, Cornelius Fendler, Aune Koitmäe, Parisa Bayat, Irene Fernandez-Cuesta, Gabriele Loers, Björn-Philipp Diercks, Ralf Fliegert, Andreas H. Guse, Carsten Ronning, Gaute Otnes, Magnus Borgström and Robert H. Blick: RSC Advances
      2019 Apr. 9 | RSC Adv.
  • Microscaffolds by Direct Laser Writing for Neurite Guidance Leading to Tailor-Made Neuronal Networks
    • Cornelius Fendler, Christian Denker, Jann Harberts, Parisa Bayat, Robert Zierold, Gabriele Loers, Markus Münzenberg, Robert H. Blick: AdvancedBioSystems
      2019 March 7 | Adv. Biosys.
  • High-Resolution Calcium Imaging Method for Local Calcium Signaling
    • Björn-Philipp Diercks, René Werner, Daniel Schetelig, Insa M Wolf, Andreas H. Guse: PMID30710265
      2019 Feb. 2 | Methods Mol Biol. | ©Springer Nature Switzerland AG, Part of Springer Nature.
  • Cellular and Molecular Mechanisms of Prion Disease
    • Christina J. Sigurdson, Jason C. Bartz, and Markus Glatzel
      2019 Jan. 24 | Annu Rev Pathol.

  • Visualization of translocons in Yersinia type III protein secretion machines during host cell infection
    • Theresa Nauth, Franziska Huschka, Michaela Schweizer, Jens B. Bosse, Andreas Diepold, Antonio Virgilio Failla, Anika Steffen, Theresia E. B. Stradal, Manuel Wolters, Martin Aepfelbacher: PMID30586431
      2018 Dec. 26 | PLOS PATHOGENS | journal.ppat.1007527
  • ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation
    • Björn-Philipp Diercks, René Werner, Paula Weidemüller, Frederik Czarniak, Lola Hernandez, Cari Lehmann, Annette Rosche, Aileen Krüger, Ulrike Kaufmann, Martin Vaeth, Antonio V. Failla, Bernd Zobiak, Farid I. Kandil, Daniel Schetelig, Alexandra Ruthenbeck, Chris Meier, Dmitri Lodygin, Alexander Flügel, Dejian Ren, Insa M. A. Wolf, Stefan Feske, Andreas H. Guse: PMID30563862
      2018 Dec. 18 | SCI Signal | scisignal.aat0358
  • Oncogenic Amplification of Zygotic Dux Factors in regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype
    • Jens Preussner, Jiasheng Zhong, Krishnamoorthy Sreenivasan, Stefan Günther, Thomas Engleitner, Carsten Künne, Markus Glatzel, Roland Rad, Mario Looso, Thomas Braun, Johnny Kim
      2018 Dec. 6 | Cell Stem Cell.
  • Comment on “Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water”
    • Gustavo Fuertes, Niccolo Banterle, Kiersten M. Ruff, Aritra Chowdhury, Rohit V. Pappu, Dmitri I. Svergun, Edward A. Lemke 2018 Aug. 31 | Science
  • Structure specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones
    • Gabriele Marcianò, Stefano Da Vela, Giancarlo Tria, Dmitri I. Svergun, Olwyn Byron and Danny T. Huang
      2018 May 15 | J Biol Chem.
  • Integration of nicotinic acid adenine dinucleotide phosphate (NAADP)-dependent calcium signalling
    • Andreas H. Guse and Björn-Philipp Diercks: PMID29635794
      2018 Apr. 26 | The Journal of Physiology © 2018 The Physiological Society.